The iQOO 16 smartphone features a 2K display with a 165 Hz refresh rate, utilizing Samsung M16 material and 2K LEAD 2.0 technology. The screen offers a brightness of 1250 nits, with peak levels exceeding 2800 nits and reaching up to 10,000 nits in specific areas. It also includes an AR anti-reflective coating and 3300 Hz PWM dimming.

Performance is driven by the Snapdragon 8 Elite Extreme Gen 6 processor paired with a proprietary Q4 gaming chip and QNSS engine. This hardware supports ray tracing, super-resolution, and frame generation. Gaming features include Q-flex touch technology, 4D vibration, 8K video recording, and an emulator for running AAA PC titles.

The camera system consists of three 50-megapixel sensors: a 1/1.3-inch main sensor, an ultra-wide module, and a Sony IMX882-based telephoto lens with 3x optical zoom. The device also incorporates Super Light and Shadow HDR technology.

The smartphone is equipped with symmetrical Pro 1511 speakers. It houses an 8400 mAh battery and supports 100W charging, while the chassis meets the IP69 protection standard.