The Acer Predator Helios Neo 16S AI features a Core Ultra 9 290HX Plus processor, Nvidia RTX 5070 Ti graphics with 115 W power, and 16GB of DDR5-6400 RAM. The device includes a 240 Hz OLED display with a 2560 x 1600 resolution and a 1TB PCIe 4.0 SSD.

The laptop measures 14.05 x 10.85 x 0.74 inches and weighs 4.85 pounds. Its port selection includes Thunderbolt 4, three USB-A 3.2 ports, USB-C 3.2, HDMI 2.1, 2.5 Gbps Ethernet, a MicroSD card reader, and an audio jack.

In performance testing, the device achieved 125 FPS in Shadow of the Tomb Raider at 1080p and 76 FPS at its native 1600p resolution. The system maintained stable thermal performance during stress tests, with the GPU averaging 74 degrees Celsius.

The chassis allows for upgrades, featuring two SODIMM slots, an M.2 2280 SSD slot, and a replaceable battery. However, the device underperformed in battery life tests compared to competitors, largely due to the 240 Hz display refresh rate.

The keyboard includes four-zone RGB lighting controlled via the PredatorSense app. The integrated speakers are noted for limited volume and bass, while the 1080p webcam provides sharp image quality but lacks a physical privacy shutter.